Structural Insights into Neonatal Fc Receptor-based Recycling Mechanisms

We report the three-dimensional structure of human neonatal Fc receptor (FcRn) bound concurrently to its two known ligands. More particularly, we solved the crystal structure of the complex between human FcRn, wild-type human serum albumin (HSA), and a human Fc engineered for improved pharmacokineti...

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Bibliografiske detaljer
Main Authors: Oganesyan, Vaheh, Damschroder, Melissa M., Cook, Kimberly E., Li, Qing, Gao, Changshou, Wu, Herren, Dall'Acqua, William F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953293/
https://ncbi.nlm.nih.gov/pubmed/24469444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.537563
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