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Mechanisms of Neutralization of a Human Anti-α-toxin Antibody
MEDI4893 is a neutralizing human monoclonal antibody that targets α-toxin (AT) and is currently undergoing evaluation in the field of Staphylococcus aureus-mediated diseases. We have solved the crystal structure of MEDI4893 Fab bound to monomeric AT at a resolution of 2.56 Å and further characterize...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4207998/ https://ncbi.nlm.nih.gov/pubmed/25210036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.601328 |
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