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Meprin Metalloproteases Inactivate Interleukin 6

Meprins have been implicated in the pathogenesis of several inflammatory diseases, including inflammatory bowel disease, in which the cytokine IL-6 is a prominent effector molecule. Because IL-6 levels are elevated markedly in meprin α and α/β knockout mice in an experimental model of inflammatory b...

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Main Authors: Keiffer, Timothy R., Bond, Judith S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953271/
https://ncbi.nlm.nih.gov/pubmed/24474695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.546309
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