A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis

Synthesis of phosphoenolpyruvate (PEP) from oxaloacetate is an absolute requirement for gluconeogenesis from mitochondrial substrates. Generally, this reaction has solely been attributed to the cytosolic isoform of PEPCK (PEPCK-C), although loss of the mitochondrial isoform (PEPCK-M) has never been...

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Autors principals: Stark, Romana, Guebre-Egziabher, Fitsum, Zhao, Xiaojian, Feriod, Colleen, Dong, Jianying, Alves, Tiago C., Ioja, Simona, Pongratz, Rebecca L., Bhanot, Sanjay, Roden, Michael, Cline, Gary W., Shulman, Gerald I., Kibbey, Richard G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
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Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953244/
https://ncbi.nlm.nih.gov/pubmed/24497630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C113.544759
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