Abnormal megakaryocyte development and platelet function in Nbeal2(−/−) mice

Gray platelet syndrome (GPS) is an inherited bleeding disorder associated with macrothrombocytopenia and α-granule-deficient platelets. GPS has been linked to loss of function mutations in NEABL2 (neurobeachin-like 2), and we describe here a murine GPS model, the Nbeal2(−/−) mouse. As in GPS, Nbeal2...

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Main Authors: Kahr, Walter H. A., Lo, Richard W., Li, Ling, Pluthero, Fred G., Christensen, Hilary, Ni, Ran, Vaezzadeh, Nima, Hawkins, Cynthia E., Weyrich, Andrew S., Di Paola, Jorge, Landolt-Marticorena, Carolina, Gross, Peter L.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2013
Teme:
Platelets and Thrombopoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3953091/
https://ncbi.nlm.nih.gov/pubmed/23861251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-04-499491
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