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DNA Dynamics during Early Double-Strand Break Processing Revealed by Non-Intrusive Imaging of Living Cells

Chromosome breakage is a major threat to genome integrity. The most accurate way to repair DNA double strand breaks (DSB) is homologous recombination (HR) with an intact copy of the broken locus. Mobility of the broken DNA has been seen to increase during the search for a donor copy. Observing chrom...

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Main Authors: Saad, Hicham, Gallardo, Franck, Dalvai, Mathieu, Tanguy-le-Gac, Nicolas, Lane, David, Bystricky, Kerstin
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952824/
https://ncbi.nlm.nih.gov/pubmed/24625580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004187
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