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A recombination execution checkpoint regulates the choice of homologous recombination pathway during DNA double-strand break repair

A DNA double-strand break (DSB) is repaired by gene conversion (GC) if both ends of the DSB share homology with an intact DNA sequence. However, if homology is limited to only one of the DSB ends, repair occurs by break-induced replication (BIR). It is not known how the homology status of the DSB en...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jain, Suvi, Sugawara, Neal, Lydeard, John, Vaze, Moreshwar, Tanguy Le Gac, Nicolas, Haber, James E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648549/
https://ncbi.nlm.nih.gov/pubmed/19204116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1751209
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