Transmigrating neutrophils shape the mucosal microenvironment through localized oxygen depletion to influence resolution of inflammation

Acute intestinal inflammation involves early accumulation of neutrophils (PMN) followed by either resolution or progression to chronic inflammation. Based on recent evidence mucosal metabolism influences disease outcomes, we hypothesized that transmigrating PMN influence the transcriptional profile...

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Main Authors: Campbell, Eric L, Bruyninckx, Walter J, Kelly, Caleb J, Glover, Louise E, McNamee, Eóin N, Bowers, Brittelle E, Bayless, Amanda J, Scully, Melanie, Saeedi, Bejan J, Golden-Mason, Lucy, Ehrentraut, Stefan F, Curtis, Valerie F, Burgess, Adrianne, Garvey, John F, Sorensen, Amber, Nemenoff, Raphael, Jedlicka, Paul, Taylor, Cormac T, Kominsky, Douglas J, Colgan, Sean P
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951457/
https://ncbi.nlm.nih.gov/pubmed/24412613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.11.020
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