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Role of energy metabolic deficits and oxidative stress in excitotoxic spinal motor neuron degeneration in vivo
MN (motor neuron) death in amyotrophic lateral sclerosis may be mediated by glutamatergic excitotoxicity. Previously, our group showed that the microdialysis perfusion of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) in the rat lumbar spinal cord induced MN death and permanent paralysis w...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Neurochemistry
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3950966/ https://ncbi.nlm.nih.gov/pubmed/24524836 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/AN20130046 |
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