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Quercetin prevents spinal motor neuron degeneration induced by chronic excitotoxic stimulus by a sirtuin 1-dependent mechanism

BACKGROUND: Excitotoxicity is a mechanism of foremost importance in the selective motor neuron degeneration characteristic of motor neuron disorders. Effective therapeutic strategies are an unmet need for these disorders. Polyphenols, such as quercetin and resveratrol, are plant-derived compounds th...

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Detalhes bibliográficos
Publicado no:Transl Neurodegener
Main Authors: Lazo-Gomez, Rafael, Tapia, Ricardo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5697078/
https://ncbi.nlm.nih.gov/pubmed/29201361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-017-0102-8
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