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Inducing Chronic Excitotoxicity in the Mouse Spinal Cord to Investigate Lower Motor Neuron Degeneration

We report the methodology for the chronic delivery of an excitotoxin to the mouse spinal cord via surgically implanted osmotic mini-pumps. Previous studies have investigated the effect of chronic application of excitotoxins in the rat, however there has been little translation of this model to the m...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Blizzard, Catherine A., Lee, K. M., Dickson, Tracey C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773442/
https://ncbi.nlm.nih.gov/pubmed/26973454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2016.00076
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