Identifying the primary site of pathogenesis in amyotrophic lateral sclerosis – vulnerability of lower motor neurons to proximal excitotoxicity

There is a desperate need for targeted therapeutic interventions that slow the progression of amyotrophic lateral sclerosis (ALS). ALS is a disorder with heterogeneous onset, which then leads to common final pathways involving multiple neuronal compartments that span both the central and peripheral...

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Dettagli Bibliografici
Pubblicato in:Dis Model Mech
Autori principali: Blizzard, Catherine A., Southam, Katherine A., Dawkins, Edgar, Lewis, Katherine E., King, Anna E., Clark, Jayden A., Dickson, Tracey C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Limited 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348560/
https://ncbi.nlm.nih.gov/pubmed/25740331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.018606
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