Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function

Altered cortical excitability and synapse dysfunction are early pathogenic events in amyotrophic lateral sclerosis (ALS) patients and animal models. Recent studies propose an important role for TAR DNA-binding protein 43 (TDP-43), the mislocalization and aggregation of which are key pathological fea...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Jiang, Tongcui, Handley, Emily, Brizuela, Mariana, Dawkins, Edgar, Lewis, Katherine E. A., Clark, Rosemary M., Dickson, Tracey C., Blizzard, Catherine A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550035/
https://ncbi.nlm.nih.gov/pubmed/31036551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.038109
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