Amyotrophic lateral sclerosis mutant TDP-43 may cause synaptic dysfunction through altered dendritic spine function

Altered cortical excitability and synapse dysfunction are early pathogenic events in amyotrophic lateral sclerosis (ALS) patients and animal models. Recent studies propose an important role for TAR DNA-binding protein 43 (TDP-43), the mislocalization and aggregation of which are key pathological fea...

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Bibliographische Detailangaben
Veröffentlicht in:Dis Model Mech
Hauptverfasser: Jiang, Tongcui, Handley, Emily, Brizuela, Mariana, Dawkins, Edgar, Lewis, Katherine E. A., Clark, Rosemary M., Dickson, Tracey C., Blizzard, Catherine A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Ltd 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6550035/
https://ncbi.nlm.nih.gov/pubmed/31036551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.038109
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