Predominance of spliceosomal complex formation over polyadenylation site selection in TDP-43 autoregulation

TDP-43 is a nuclear protein involved in many aspects of RNA metabolism. To ensure cellular viability, its expression levels within cells must be tightly regulated. We have previously demonstrated that TDP-43 autoregulation occurs through the activation of a normally silent intron in its 3′-UTR seque...

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Huvudupphovsmän: Bembich, Sara, Herzog, Jeremias S., De Conti, Laura, Stuani, Cristiana, Avendaño-Vázquez, S. Eréndira, Buratti, Emanuele, Baralle, Marco, Baralle, Francisco E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2014
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950720/
https://ncbi.nlm.nih.gov/pubmed/24369426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1343
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