Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection

TDP-43 is a critical RNA-binding factor associated with pre-mRNA splicing in mammals. Its expression is tightly autoregulated, with loss of this regulation implicated in human neuropathology. We demonstrate that TDP-43 overexpression in humans and mice activates a 3′ untranslated region (UTR) intron...

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Main Authors: Avendaño-Vázquez, S. Eréndira, Dhir, Ashish, Bembich, Sara, Buratti, Emanuele, Proudfoot, Nicholas, Baralle, Francisco E.
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418585/
https://ncbi.nlm.nih.gov/pubmed/22855830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.194829.112
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