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Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection
TDP-43 is a critical RNA-binding factor associated with pre-mRNA splicing in mammals. Its expression is tightly autoregulated, with loss of this regulation implicated in human neuropathology. We demonstrate that TDP-43 overexpression in humans and mice activates a 3′ untranslated region (UTR) intron...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3418585/ https://ncbi.nlm.nih.gov/pubmed/22855830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.194829.112 |
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