Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon

Eukaryotic initiator tRNA (tRNA(i)) contains several highly conserved unique sequence features, but their importance in accurate start codon selection was unknown. Here we show that conserved bases throughout tRNA(i), from the anticodon stem to acceptor stem, play key roles in ensuring the fidelity...

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Hlavní autoři: Dong, Jinsheng, Munoz, Antonio, Kolitz, Sarah E., Saini, Adesh K., Chiu, Wen-ling, Rahman, Hafsa, Lorsch, Jon R., Hinnebusch, Alan G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2014
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3950347/
https://ncbi.nlm.nih.gov/pubmed/24589778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.236547.113
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