Increased Dynamic Effects in a Catalytically Compromised Variant of Escherichia coli Dihydrofolate Reductase

[Image: see text] Isotopic substitution ((15)N, (13)C, (2)H) of a catalytically compromised variant of Escherichia coli dihydrofolate reductase, EcDHFR-N23PP/S148A, has been used to investigate the effect of these mutations on catalysis. The reduction of the rate constant of the chemical step in the...

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Hauptverfasser: Ruiz-Pernia, J. Javier, Luk, Louis Y. P., García-Meseguer, Rafael, Martí, Sergio, Loveridge, E. Joel, Tuñón, Iñaki, Moliner, Vicent, Allemann, Rudolf K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3949409/
https://ncbi.nlm.nih.gov/pubmed/24252106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja410519h
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