Bufalin is a potent small molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1

Virtually all transcription factors partner with coactivators that recruit chromatin remodeling factors and interact with the basal transcription machinery. Coactivators have been implicated in cancer cell proliferation, invasion and metastasis, including the p160 steroid receptor coactivator (SRC)...

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Autori principali: Wang, Ying, Lonard, David M., Yu, Yang, Chow, Dar-Chone, Palzkill, Timothy G., Wang, Jin, Qi, Ruogu, Matzuk, Alexander J., Song, Xianzhou, Madoux, Franck, Hodder, Peter, Chase, Peter, Griffin, Patrick R., Zhou, Suoling, Liao, Lan, Xu, Jianming, O’Malley, Bert W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947477/
https://ncbi.nlm.nih.gov/pubmed/24390736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2939
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