Characterization of Defects in Ion Transport and Tissue Development in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Knockout Rats

Animal models for cystic fibrosis (CF) have contributed significantly to our understanding of disease pathogenesis. Here we describe development and characterization of the first cystic fibrosis rat, in which the cystic fibrosis transmembrane conductance regulator gene (CFTR) was knocked out using a...

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Main Authors: Tuggle, Katherine L., Birket, Susan E., Cui, Xiaoxia, Hong, Jeong, Warren, Joe, Reid, Lara, Chambers, Andre, Ji, Diana, Gamber, Kevin, Chu, Kengyeh K., Tearney, Guillermo, Tang, Li Ping, Fortenberry, James A., Du, Ming, Cadillac, Joan M., Bedwell, David M., Rowe, Steven M., Sorscher, Eric J., Fanucchi, Michelle V.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946746/
https://ncbi.nlm.nih.gov/pubmed/24608905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091253
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