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Insight into α-Synuclein Plasticity and Misfolding from Differential Micelle Binding
Misfolded species of the 140-residue protein α-synuclein (αS) are implicated in the demise of dopaminergic neurons resulting in fatal neurodegeneration. The intrinsically unstructured protein binds curved synaptic vesicle membranes in helical conformations but misfolds into amyloid fibrils via β-she...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3946565/ https://ncbi.nlm.nih.gov/pubmed/23978162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp402589x |
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