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Clustering and Spatial Arrangement of β-Sheet Sequence, but not Order, Govern α-Synuclein Fibrillogenesis

The intrinsically unstructured protein α-synuclein (aS) is prone to misfold into cytotoxic β-sheet-rich oligomers and amyloid fibrils that underlie the pathogenesis of Lewy body diseases such as Parkinson's disease. An important, recognized fibrillogenesis parameter is amino acid content, where...

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Bibliographic Details
Main Authors: Suk, Jae-Eun, Lokappa, Sowmya Bekshe, Ulmer, Tobias S.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841006/
https://ncbi.nlm.nih.gov/pubmed/20121219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901753h
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