Wird geladen...

Clustering and Spatial Arrangement of β-Sheet Sequence, but not Order, Govern α-Synuclein Fibrillogenesis

The intrinsically unstructured protein α-synuclein (aS) is prone to misfold into cytotoxic β-sheet-rich oligomers and amyloid fibrils that underlie the pathogenesis of Lewy body diseases such as Parkinson's disease. An important, recognized fibrillogenesis parameter is amino acid content, where...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Suk, Jae-Eun, Lokappa, Sowmya Bekshe, Ulmer, Tobias S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2841006/
https://ncbi.nlm.nih.gov/pubmed/20121219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901753h
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!