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Clustering and Spatial Arrangement of β-Sheet Sequence, but not Order, Govern α-Synuclein Fibrillogenesis
The intrinsically unstructured protein α-synuclein (aS) is prone to misfold into cytotoxic β-sheet-rich oligomers and amyloid fibrils that underlie the pathogenesis of Lewy body diseases such as Parkinson's disease. An important, recognized fibrillogenesis parameter is amino acid content, where...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841006/ https://ncbi.nlm.nih.gov/pubmed/20121219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901753h |
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