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Computational insights into the role of α-strand/sheet in aggregation of α-synuclein

The α-synuclein is a major component of amyloid fibrils found in Lewy bodies, the characteristic intracellular proteinaceous deposits which are pathological hallmarks of neurodegenerative diseases such as Parkinson’s disease (PD) and dementia. It is an intrinsically disordered protein that may under...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Balupuri, Anand, Choi, Kwang-Eun, Kang, Nam Sook
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329781/
https://ncbi.nlm.nih.gov/pubmed/30635607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37276-1
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