טוען...
Clustering and Spatial Arrangement of β-Sheet Sequence, but not Order, Govern α-Synuclein Fibrillogenesis
The intrinsically unstructured protein α-synuclein (aS) is prone to misfold into cytotoxic β-sheet-rich oligomers and amyloid fibrils that underlie the pathogenesis of Lewy body diseases such as Parkinson's disease. An important, recognized fibrillogenesis parameter is amino acid content, where...
שמור ב:
| Main Authors: | , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2010
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841006/ https://ncbi.nlm.nih.gov/pubmed/20121219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901753h |
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