Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification

Amyloid fibril formation has been implicated in the pathogenesis of neurodegenerative diseases. Fibrillation generates numerous conformers. Presumably, the conformers may possess specific biological properties, thus providing a biochemical framework for strains of prions. However, the precise relati...

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Detalhes bibliográficos
Publicado no:Exp Mol Med
Main Authors: Jung, Byung Chul, Lim, Yoon-Ju, Bae, Eun-Jin, Lee, Jun Sung, Choi, Min Sun, Lee, Michael K, Lee, He-Jin, Kim, Yoon Suk, Lee, Seung-Jae
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5420798/
https://ncbi.nlm.nih.gov/pubmed/28386127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.1
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