Amplification of distinct α-synuclein fibril conformers through protein misfolding cyclic amplification

Amyloid fibril formation has been implicated in the pathogenesis of neurodegenerative diseases. Fibrillation generates numerous conformers. Presumably, the conformers may possess specific biological properties, thus providing a biochemical framework for strains of prions. However, the precise relati...

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Vydáno v:Exp Mol Med
Hlavní autoři: Jung, Byung Chul, Lim, Yoon-Ju, Bae, Eun-Jin, Lee, Jun Sung, Choi, Min Sun, Lee, Michael K, Lee, He-Jin, Kim, Yoon Suk, Lee, Seung-Jae
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5420798/
https://ncbi.nlm.nih.gov/pubmed/28386127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2017.1
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