Attenuation of Hedgehog Acyltransferase-Catalyzed Sonic Hedgehog Palmitoylation Causes Reduced Signaling, Proliferation and Invasiveness of Human Carcinoma Cells

Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat). In a pancreatic ductal adenocarcinoma (PDAC) ce...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Konitsiotis, Antonios D., Chang, Shu-Chun, Jovanović, Biljana, Ciepla, Paulina, Masumoto, Naoko, Palmer, Christopher P., Tate, Edward W., Couchman, John R., Magee, Anthony I.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2014
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946499/
https://ncbi.nlm.nih.gov/pubmed/24608521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089899
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