Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase

Hedgehog signaling is critical for correct embryogenesis and tissue development. However, on maturation, signaling is also found to be aberrantly activated in many cancers. Palmitoylation of the secreted signaling protein sonic hedgehog (Shh) by the enzyme hedgehog acyltransferase (Hhat) is required...

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Bibliographische Detailangaben
Veröffentlicht in:Anal Biochem
Hauptverfasser: Lanyon-Hogg, Thomas, Masumoto, Naoko, Bodakh, George, Konitsiotis, Antonio D., Thinon, Emmanuelle, Rodgers, Ursula R., Owens, Raymond J., Magee, Anthony I., Tate, Edward W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Academic Press 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615133/
https://ncbi.nlm.nih.gov/pubmed/26334609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2015.08.025
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