Attenuation of Hedgehog Acyltransferase-Catalyzed Sonic Hedgehog Palmitoylation Causes Reduced Signaling, Proliferation and Invasiveness of Human Carcinoma Cells

Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat). In a pancreatic ductal adenocarcinoma (PDAC) ce...

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Detalhes bibliográficos
Main Authors: Konitsiotis, Antonios D., Chang, Shu-Chun, Jovanović, Biljana, Ciepla, Paulina, Masumoto, Naoko, Palmer, Christopher P., Tate, Edward W., Couchman, John R., Magee, Anthony I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946499/
https://ncbi.nlm.nih.gov/pubmed/24608521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089899
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