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Topological Analysis of Hedgehog Acyltransferase, a Multipalmitoylated Transmembrane Protein

Hedgehog proteins are secreted morphogens that play critical roles in development and disease. During maturation of the proteins through the secretory pathway, they are modified by the addition of N-terminal palmitic acid and C-terminal cholesterol moieties, both of which are critical for their corr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Konitsiotis, Antonio D., Jovanović, Biljana, Ciepla, Paulina, Spitaler, Martin, Lanyon-Hogg, Thomas, Tate, Edward W., Magee, Anthony I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4319003/
https://ncbi.nlm.nih.gov/pubmed/25505265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.614578
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