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Membrane Topology of Hedgehog Acyltransferase

Hedgehog acyltransferase (Hhat) is a multipass transmembrane enzyme that mediates the covalent attachment of the 16-carbon fatty acid palmitate to the N-terminal cysteine of Sonic Hedgehog (Shh). Palmitoylation of Shh by Hhat is critical for short and long range signaling. Knowledge of the topologic...

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Vydáno v:J Biol Chem
Hlavní autoři: Matevossian, Armine, Resh, Marilyn D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303674/
https://ncbi.nlm.nih.gov/pubmed/25488661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.625764
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