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Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease

Hedgehog acyltransferase (Hhat), a member of the membrane-bound O-acyltransferase (MBOAT) family, catalyses the covalent attachment of palmitate to the N-terminus of Hedgehog proteins. Palmitoylation is a post-translational modification essential for Hedgehog signalling. This review explores the mec...

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Detalles Bibliográficos
Publicado en:Open Biol
Autor principal: Resh, Marilyn D.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Royal Society 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8061759/
https://ncbi.nlm.nih.gov/pubmed/33653085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.200414
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