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Identification of Conserved Regions and Residues within Hedgehog Acyltransferase Critical for Palmitoylation of Sonic Hedgehog

BACKGROUND: Sonic hedgehog (Shh) is a palmitoylated protein that plays key roles in mammalian development and human cancers. Palmitoylation of Shh is required for effective long and short range Shh-mediated signaling. Attachment of palmitate to Shh is catalyzed by Hedgehog acyltransferase (Hhat), a...

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書誌詳細
主要な著者: Buglino, John A., Resh, Marilyn D.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890405/
https://ncbi.nlm.nih.gov/pubmed/20585641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0011195
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