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New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish
Sonic Hedgehog protein (Shh) is a morphogen molecule important in embryonic development and in the progression of many cancer types in which it is aberrantly overexpressed. Fully mature Shh requires attachment of cholesterol and palmitic acid to its C- and N-termini, respectively. The study of lipid...
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| Publicat a: | Chem Sci |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Royal Society of Chemistry
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4285107/ https://ncbi.nlm.nih.gov/pubmed/25574372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc01600a |
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