New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish

Sonic Hedgehog protein (Shh) is a morphogen molecule important in embryonic development and in the progression of many cancer types in which it is aberrantly overexpressed. Fully mature Shh requires attachment of cholesterol and palmitic acid to its C- and N-termini, respectively. The study of lipid...

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Detaylı Bibliyografya
Yayımlandı:Chem Sci
Asıl Yazarlar: Ciepla, Paulina, Konitsiotis, Antonios D., Serwa, Remigiusz A., Masumoto, Naoko, Leong, Wai P., Dallman, Margaret J., Magee, Anthony I., Tate, Edward W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Royal Society of Chemistry 2014
Konular:
Chemistry
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4285107/
https://ncbi.nlm.nih.gov/pubmed/25574372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc01600a
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