Chronic Exposure to Type-I IFN under Lymphopenic Conditions Alters CD4 T Cell Homeostasis

HIV infection and the associated chronic immune activation alter T cell homeostasis leading to CD4 T cell depletion and CD8 T cell expansion. The mechanisms behind these outcomes are not totally defined and only partially explained by the direct cytopathic effect of the virus. In this manuscript, we...

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Détails bibliographiques
Auteurs principaux: Le Saout, Cecile, Hasley, Rebecca B., Imamichi, Hiromi, Tcheung, Lueng, Hu, Zonghui, Luckey, Megan A., Park, Jung-Hyun, Durum, Scott K., Smith, Mindy, Rupert, Adam W., Sneller, Michael C., Lane, H. Clifford, Catalfamo, Marta
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946368/
https://ncbi.nlm.nih.gov/pubmed/24603698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003976
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