Enhanced Effector Function of CD8(+) T Cells From Healthy Controls and HIV-Infected Patients Occurs Through Thrombin Activation of Protease-Activated Receptor 1

Disruption of vascular integrity by trauma and other tissue insults leads to inflammation and activation of the coagulation cascade. The serine protease thrombin links these 2 processes. The proinflammatory function of thrombin is mediated by activation of protease-activated receptor 1 (PAR-1). We f...

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Main Authors: Hurley, Amanda, Smith, Mindy, Karpova, Tatiana, Hasley, Rebecca B., Belkina, Natalya, Shaw, Stephen, Balenga, Nariman, Druey, Kirk M., Nickel, Erin, Packard, Beverly, Imamichi, Hiromi, Hu, Zonghui, Follmann, Dean, McNally, James, Higgins, Jeanette, Sneller, Michael, Lane, H. Clifford, Catalfamo, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549602/
https://ncbi.nlm.nih.gov/pubmed/23204166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis730
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