Enhanced Effector Function of CD8(+) T Cells From Healthy Controls and HIV-Infected Patients Occurs Through Thrombin Activation of Protease-Activated Receptor 1

Disruption of vascular integrity by trauma and other tissue insults leads to inflammation and activation of the coagulation cascade. The serine protease thrombin links these 2 processes. The proinflammatory function of thrombin is mediated by activation of protease-activated receptor 1 (PAR-1). We f...

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Autori principali: Hurley, Amanda, Smith, Mindy, Karpova, Tatiana, Hasley, Rebecca B., Belkina, Natalya, Shaw, Stephen, Balenga, Nariman, Druey, Kirk M., Nickel, Erin, Packard, Beverly, Imamichi, Hiromi, Hu, Zonghui, Follmann, Dean, McNally, James, Higgins, Jeanette, Sneller, Michael, Lane, H. Clifford, Catalfamo, Marta
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2013
Soggetti:
Major Articles and Brief Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549602/
https://ncbi.nlm.nih.gov/pubmed/23204166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis730
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