Enhanced Effector Function of CD8(+) T Cells From Healthy Controls and HIV-Infected Patients Occurs Through Thrombin Activation of Protease-Activated Receptor 1

Disruption of vascular integrity by trauma and other tissue insults leads to inflammation and activation of the coagulation cascade. The serine protease thrombin links these 2 processes. The proinflammatory function of thrombin is mediated by activation of protease-activated receptor 1 (PAR-1). We f...

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Główni autorzy: Hurley, Amanda, Smith, Mindy, Karpova, Tatiana, Hasley, Rebecca B., Belkina, Natalya, Shaw, Stephen, Balenga, Nariman, Druey, Kirk M., Nickel, Erin, Packard, Beverly, Imamichi, Hiromi, Hu, Zonghui, Follmann, Dean, McNally, James, Higgins, Jeanette, Sneller, Michael, Lane, H. Clifford, Catalfamo, Marta
Format: Artigo
Język:Inglês
Wydane: Oxford University Press 2013
Hasła przedmiotowe:
Major Articles and Brief Reports
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549602/
https://ncbi.nlm.nih.gov/pubmed/23204166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis730
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