IL-7–dependent STAT1 activation limits homeostatic CD4(+) T cell expansion

IL-7 regulates homeostatic mechanisms that maintain the overall size of the T cell pool throughout life. We show that, under steady-state conditions, IL-7 signaling is principally mediated by activation of signal transducers and activators of transcription 5 (STAT5). In contrast, under lymphopenic c...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Le Saout, Cecile, Luckey, Megan A., Villarino, Alejandro V., Smith, Mindy, Hasley, Rebecca B., Myers, Timothy G., Imamichi, Hiromi, Park, Jung-Hyun, O’Shea, John J., Lane, H. Clifford, Catalfamo, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5752389/
https://ncbi.nlm.nih.gov/pubmed/29202461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.96228
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