HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127

BACKGROUND: During HIV infection distinct mechanisms drive immune activation of the CD4 and CD8 T cells leading to CD4 T-cell depletion and expansion of the CD8 T-cell pool. This immune activation is polyclonal and extends beyond HIV-specific T cells. One consequence of this immune activation is a p...

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Publicado no:AIDS
Main Authors: Hasley, Rebecca B., Hong, Changwan, Li, Wenqing, Friesen, Travis, Nakamura, Yoriko, Kim, Grace Y., Park, Jung-Hyun, Hixon, Julie A., Durum, Scott, Hu, Zonghui, Sneller, Michael C., Oguariri, Raphael, Imamichi, Tomozumi, Lane, H. Clifford, Catalfamo, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7577351/
https://ncbi.nlm.nih.gov/pubmed/23965471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283618487
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