Rapid induction of Alternative Lengthening of Telomeres by depletion of the histone chaperone ASF1

The mechanism of activation of the Alternative Lengthening of Telomeres (ALT) pathway of mammalian chromosome end maintenance has remained an unresolved issue. We have discovered that co-depletion of the histone chaperones ASF1a and ASF1b in human cells induced all hallmarks of ALT in both primary a...

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Main Authors: O’Sullivan, Roderick J., Arnoult, Nausica, Lackner, Daniel H., Oganesian, Liana, Haggblom, Candy, Corpet, Armelle, Almouzni, Genevieve, Karlseder, Jan
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946341/
https://ncbi.nlm.nih.gov/pubmed/24413054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2754
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