Rapid induction of Alternative Lengthening of Telomeres by depletion of the histone chaperone ASF1

The mechanism of activation of the Alternative Lengthening of Telomeres (ALT) pathway of mammalian chromosome end maintenance has remained an unresolved issue. We have discovered that co-depletion of the histone chaperones ASF1a and ASF1b in human cells induced all hallmarks of ALT in both primary a...

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Main Authors: O’Sullivan, Roderick J., Arnoult, Nausica, Lackner, Daniel H., Oganesian, Liana, Haggblom, Candy, Corpet, Armelle, Almouzni, Genevieve, Karlseder, Jan
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946341/
https://ncbi.nlm.nih.gov/pubmed/24413054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2754
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