Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets

Neoadjuvant chemotherapy (NAC) induces a pathologic complete response (pCR) in approximately 30% of patients with triple-negative breast cancers (TNBC). In patients lacking a pCR, NAC selects a subpopulation of chemotherapy-resistant tumor cells. To understand the molecular underpinnings driving tre...

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Main Authors: Balko, Justin M., Giltnane, Jennifer M., Wang, Kai, Schwarz, Luis J., Young, Christian D., Cook, Rebecca S., Owens, Phillip, Sanders, Melinda E., Kuba, Maria G., Sánchez, Violeta, Kurupi, Richard, Moore, Preston D., Pinto, Joseph A., Doimi, Franco D., Gómez, Henry, Horiuchi, Dai, Goga, Andrei, Lehmann, Brian D., Bauer, Joshua A., Pietenpol, Jennifer A., Ross, Jeffrey S., Palmer, Gary A., Yelensky, Roman, Cronin, Maureen, Miller, Vincent A., Stephens, Phillip J., Arteaga, Carlos L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946308/
https://ncbi.nlm.nih.gov/pubmed/24356096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0286
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