Triple negative breast cancers with amplification of JAK2 at the 9p24 loci demonstrate JAK2-specific dependence

Amplifications at 9p24 have been identified in breast cancer and other malignancies, but the genes within this locus casually associated with oncogenicity or tumor progression remain unclear. Targeted next-generation sequencing of post-chemotherapy triple-negative breast cancers (TNBC) identified a...

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Veröffentlicht in:Sci Transl Med
Hauptverfasser: Balko, Justin M., Schwarz, Luis J., Cook, Rebecca S., Estrada, Monica V., Giltnane, Jennifer M., Sanders, Melinda E., Sánchez, Violeta, Dean, Phillip T., Wang, Kai, Combs, Susan E., Hicks, Donna, Pinto, Joseph A., Landis, Melissa D., Chang, Jenny C., Doimi, Franco D., Gómez, Henry, Rimm, David L., Yelensky, Roman, Miller, Vincent A., Stephens, Phillip J., Arteaga, Carlos L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256931/
https://ncbi.nlm.nih.gov/pubmed/27075627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aad3001
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