Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets

Neoadjuvant chemotherapy (NAC) induces a pathologic complete response (pCR) in approximately 30% of patients with triple-negative breast cancers (TNBC). In patients lacking a pCR, NAC selects a subpopulation of chemotherapy-resistant tumor cells. To understand the molecular underpinnings driving tre...

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Main Authors: Balko, Justin M., Giltnane, Jennifer M., Wang, Kai, Schwarz, Luis J., Young, Christian D., Cook, Rebecca S., Owens, Phillip, Sanders, Melinda E., Kuba, Maria G., Sánchez, Violeta, Kurupi, Richard, Moore, Preston D., Pinto, Joseph A., Doimi, Franco D., Gómez, Henry, Horiuchi, Dai, Goga, Andrei, Lehmann, Brian D., Bauer, Joshua A., Pietenpol, Jennifer A., Ross, Jeffrey S., Palmer, Gary A., Yelensky, Roman, Cronin, Maureen, Miller, Vincent A., Stephens, Phillip J., Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946308/
https://ncbi.nlm.nih.gov/pubmed/24356096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0286
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