Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design

Species of the fungal genus Aspergillus are significant human and agricultural pathogens that are often refractory to existing antifungal treatments. Protein farnesyltransferase (FTase), a critical enzyme in eukaryotes, is an attractive potential target for antifungal drug discovery. We report high-...

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Auteurs principaux: Mabanglo, Mark F, Hast, Michael A, Lubock, Nathan B, Hellinga, Homme W, Beese, Lorena S
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945837/
https://ncbi.nlm.nih.gov/pubmed/24347326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2411
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