Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens

Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in immunocompromised individuals, including AIDS patients and transplant recipients. Few antifungals can treat C. neoformans infections, and drug resistance is increasing. Protein farnesyltransferase (FTase) catalyz...

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Detalhes bibliográficos
Main Authors: Hast, Michael A., Nichols, Connie B., Armstrong, Stephanie M., Kelly, Shannon M., Hellinga, Homme W., Alspaugh, J. Andrew, Beese, Lorena S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186413/
https://ncbi.nlm.nih.gov/pubmed/21816822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.250506
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