Kinetics of Tumor Destruction by Chimeric Antigen Receptor-modified T Cells

The use of chimeric antigen receptor (CAR)–modified T cells as a therapy for hematologic malignancies and solid tumors is becoming more widespread. However, the infusion of a T-cell product targeting a single tumor-associated antigen may lead to target antigen modulation under this selective pressur...

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Autors principals: Anurathapan, Usanarat, Chan, Robert C, Hindi, Hakeem F, Mucharla, Roopa, Bajgain, Pradip, Hayes, Brendan C, Fisher, William E, Heslop, Helen E, Rooney, Cliona M, Brenner, Malcolm K, Leen, Ann M, Vera, Juan F
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945803/
https://ncbi.nlm.nih.gov/pubmed/24213558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.262
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