WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis.

The Wilms tumor suppressor gene WT1 encodes a developmentally regulated transcription factor that is mutated in a subset of embryonal tumors. To test its functional properties, we developed osteosarcoma cell lines expressing WT1 under an inducible tetracycline-regulated promoter. Induction of WT1 re...

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Bibliographic Details
Main Authors: Englert, C, Hou, X, Maheswaran, S, Bennett, P, Ngwu, C, Re, G G, Garvin, A J, Rosner, M R, Haber, D A
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC394563/
https://ncbi.nlm.nih.gov/pubmed/7588596
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